Journal article
Alanine aminotransferase, HCV RNA levels and pro-inflammatory and pro-fibrogenic cytokines/chemokines during acute hepatitis C virus infection
B Hajarizadeh, FMJ Lamoury, JJ Feld, J Amin, E Keoshkerian, GV Matthews, M Hellard, GJ Dore, AR Lloyd, J Grebely, TL Applegate
Virology Journal | BMC | Published : 2016
Abstract
Background: This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to provide further insight into the potential HCV immunopathogenesis. Methods: Participants in the ATAHC study, a prospective study of recent HCV infection, with detectable HCV RNA at the time of HCV detection were included. Plasma levels of 27 cytokines and chemokines were measured and their correlation with ALT and HCV RNA levels were assessed. Log10 transformed cytokines and ALT values were used in the analysis. Results: Among 117 individuals, the plasma levels of interferon-gam..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank the study participants and volunteers for their contribution to the research. This research was supported by the National Health and Medical Research Council (NHMRC) grant HIV and HCV vaccines and immunopathogenesis (#510448) and UNSW Goldstar research grant. The ATAHC study was supported by the National Institutes of Health (#RO1 DA 15999-01). The Kirby Institute is funded by the Australian Government Department of Health and Ageing and is affiliated with the Faculty of Medicine, UNSW Australia.